ea0034oc5.1 | Pituitary | SFEBES2014
Stevenson Mark
, Piret Sian
, Javid Mahsa
, Bishop Tammie
, Reed Anita
, Walls Gerard
, Gaynor Katie
, Newey Paul
, Christie Paul
, Nicholls Lynn
, Ratcliffe Peter
, Thakker Rajesh
Cumulative genetic abnormalities within an oncogenic pathway may contribute to earlier onset or increased aggressiveness of cancers. An example in human and murine cancer is the dysregulation of Wnt signalling by inactivation of the adenomatous polyposis coli (APC) gene that results in accumulation of nuclear β-catenin and earlier onset of renal cell carcinoma, which can be accelerated by p53-deficiency. We therefore investigated the effects of such cumulative genetic abn...